Early detection of acute myocardial infarction with the new marker Fatty Acid-Binding Protein : rapid testing and diagnostic value

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dc.contributor Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong de_CH
dc.contributor Institut für Physikalische und Theoretische Chemie de_DE
dc.contributor.author Kaptein, Helma de_DE
dc.contributor.author Chan, Cangel de_DE
dc.contributor.author Sanderson, John de_DE
dc.contributor.author Glatz, Jan de_DE
dc.contributor.author Leung, Wing de_DE
dc.contributor.author Renneberg, Reinhard de_DE
dc.contributor.other Gauglitz, Günter de_DE
dc.date.accessioned 2001-11-12 de_DE
dc.date.accessioned 2014-03-18T10:09:25Z
dc.date.available 2001-11-12 de_DE
dc.date.available 2014-03-18T10:09:25Z
dc.date.issued 2001 de_DE
dc.identifier.other 099524295 de_DE
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-opus-3617 de_DE
dc.identifier.uri http://hdl.handle.net/10900/48251
dc.description.abstract There are several requirements for the early detection of AMI with biochemical markers: The biochemical marker should be: - Specific - Sensitive - Fast elevated after the clinical onset of the symptoms. The test should be: - Easy to perform - Give a fast result - Preferably bedside - Inexpensive Here, we demonstrate the biochemical characteristics of heart-type Fatty Acid-Binding Protein (FABP) in AMI and UAP patients. Also, we show some preliminary data on a new in-house made quantitative rapid test with simple test procedures. - Patients: 50 patients of the CCU of PWH are included in the study diagnosed with UAP or AMI. Eight blood samples per patient were taken at 0-72 hours after admission and analyzed with a laboratory ELISA test. - Rapid test procedure: 80 ml plasma or serum is added on the sample pad. Within 5 minutes, the strip can be read out with an optical reader (the PART from LRE, Munich, Germany). A release curve for AMI patients shows a significantly elevated FABP concentration already 1 hour after infarction, whereas for CPK, this is found after 3 hours. Comparing the ROC curve for patients arriving at the hospital and 1 hour later for FABP and CPK demonstrates the preference of FABP over CPK. The preliminary results of the rapid test show for selected plasma and serum samples a measuring range of 0-200 ng/ml FABP. The availability of a rapid bedside test for FABP enables faster diagnosis in patients with no clear ECG. This can be used for both inclusion or exclusion of AMI. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-nopod de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ubt-nopod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ubt-nopod.php?la=en en
dc.subject.classification Biosensor , Herzinfarkt de_DE
dc.subject.ddc 540 de_DE
dc.title Early detection of acute myocardial infarction with the new marker Fatty Acid-Binding Protein : rapid testing and diagnostic value en
dc.type Other de_DE
dc.date.updated 2010-02-10 de_DE
utue.publikation.fachbereich Sonstige - Chemie und Pharmazie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
dcterms.DCMIType Text de_DE
utue.publikation.typ report de_DE
utue.opus.id 361 de_DE
utue.publikation.source http://barolo.ipc.uni-tuebingen.de/biosensor2001/ de_DE


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