Understanding Transient Network Effects Triggered by Spontaneous Events during Sleep with Biophysical and Statistical Models

DSpace Repository

Show simple item record

dc.contributor.advisor Logothetis, Nikos K. (Prof. Dr.)
dc.contributor.author Shao, Kaidi
dc.date.accessioned 2022-03-29T08:02:53Z
dc.date.available 2022-03-29T08:02:53Z
dc.date.issued 2023-12-15
dc.identifier.uri http://hdl.handle.net/10900/125632
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1256328 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-66995
dc.description.abstract Sleep and its major functions require the precise coordination of transient mechanisms at multiple spatiotemporal scales, which are reflected in neural signals by the spontaneous occurrence of transient neural events. At the systems level, the network dynamics determine how and when such events are generated. Conversely, the occurrence of events influences the underlying network properties. We are interested in the interplay between the events and the underlying network mechanisms to address the potential functions of transient activity during sleep. In this thesis, we achieve this goal with both biophysical and statistical modelling approaches. In the first project, we build a biophysically interpretable model of PGO waves based on network mechanisms at different levels and make prediction about PGO-triggered plasticity. In the second project, we apply statistical models that take manageable forms and estimate peri-event dynamics from data. Although this does not explicitly account for detailed biological mechanisms, we show that they can provide qualitative insights through causality analysis. Finally, by combining models of both perspectives, we propose a hybrid framework that integrates experimental data with models to estimate biologically meaningful parameters and recover hidden brain states. en
dc.description.abstract Dissertation ist gesperrt bis zum 15.12.2023 !!! de_DE
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.ddc 000 de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.title Understanding Transient Network Effects Triggered by Spontaneous Events during Sleep with Biophysical and Statistical Models en
dc.type Dissertation de_DE
dcterms.dateAccepted 2021-12-15
utue.publikation.fachbereich Biologie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.noppn yes de_DE


This item appears in the following Collection(s)

Show simple item record