Characterizing the molecular signatures induced by oncolytic measles virus along with conventional therapies in experimental glioma

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dc.contributor.advisor Tabatabai, Ghazaleh (Prof. Dr. Dr.)
dc.contributor.author Rajaraman, Srinath
dc.date.accessioned 2019-01-23T08:00:45Z
dc.date.available 2019-01-23T08:00:45Z
dc.date.issued 2020-12-18
dc.identifier.other 1743191286 de_DE
dc.identifier.uri http://hdl.handle.net/10900/85880
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-858804 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-27269
dc.description.abstract Scientific Objectives 1. To determine the feasibility of oncolytic virotherapy using MeV in glioblastoma through characterization of glioma cell lines and primary glioblastoma cell cultures in vitro. 2. To identify a synergistic combination of MeV with SOC, radiotherapy and alkylating chemotherapy in glioma cell lines (LN229 and LNZ308), glioma stem-like cells (GS8) and temozolomide-resistant LN229 cells (R-LN229) in vitro. 3. To characterize and validate the molecular mechanisms of synergy in the combinatorial treatment regimen through transcriptome analysis using RNA sequencing. 4. To delineate the treatment-induced immunological profile of MeV-infected glioma cells established through presentation of antigens using HLA ligandome analysis. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en en
dc.subject.classification Gliom , Masern , Synergie de_DE
dc.subject.ddc 570 de_DE
dc.subject.ddc 610 de_DE
dc.subject.other Glioma en
dc.subject.other oncolytic measles virus en
dc.subject.other synergy en
dc.title Characterizing the molecular signatures induced by oncolytic measles virus along with conventional therapies in experimental glioma en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2018-12-18
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE

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