Nachweisgrenzen der Mikroskopie von Plasmodium falciparum in einem endemischen Malariagebiet Zentralafrikas

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URI: http://hdl.handle.net/10900/63000
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-630002
http://dx.doi.org/10.15496/publikation-4422
Dokumentart: PhDThesis
Date: 2015-05
Language: German
Faculty: 4 Medizinische Fakultät
Department: Medizin
Advisor: Kremsner, Peter Gottfried (Prof. Dr.)
Day of Oral Examination: 2015-04-13
DDC Classifikation: 610 - Medicine and health
Keywords: Malaria , Mikroskopie
Other Keywords: Nachweisgrenzen
Dicker Tropfen
limit of detection
diagnosis
microscopy
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Abstract:

Proper malaria diagnosis depends on the detection of asexual forms of Plasmodium spp. in the blood. Thick blood smear microscopy is the accepted gold standard of malaria diagnosis and is widely implemented. Surprisingly, diagnostic performance of this method is not well investigated and many clinicians in African routine settings base treatment decisions independent of microscopy results. This leads to overtreatment and poor management of other febrile diseases. Implementation of quality control programmes is recommended, but requires sustained funding, external logistic support and constant training and supervision of the staff. This study describes an easily applicable method to assess the performance of thick blood smear microscopy by determining the limit of blank and limit of detection. These two values are representative of the diagnostic quality and allow the correct discrimination between positive and negative samples.

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