Abstract:
Numerous studies have demonstrated the increased prophylactic effect of low molecular weight heparin compared with unfractionated heparin.
In the present study, the intravenous administration of dalteparin (Fragmin) was investigated in comparison with unfractionated heparin (UFH) in the carotid reconstructive surgery.
80 patients were enrolled in the study.
The primary objective of this prospective study is to investigate the variability of the anti-factor Xa activity and anti-factor IIa activity after intravenous administration of UFH or dalteparin for intraoperative arterial thrombosis prophylaxis in reconstructive carotid surgery.
The test hypothesis that the intraoperative use of dalteparin in the carotid TEA is associated with a lower variability of the anti-F-Xa activity and anti-F-IIa activity as compared to the use of UFH could, by a significant difference (p < 0.0001) of the variability of both groups according to Brown-Forsythe test demonstrated.
These advantages, combined with increased effectiveness and fewer complications make low molecular weight heparins (eg dalteparin) is interesting not only for subcutaneous administration, but also for intraoperative use for intravenous application in vascular surgery.
Dalteparin is a weight-adapted recommended dose of 2,000 IU to 3,500 IU Fragmin i.v.very suitable for the prophylaxis of thromboembolic complications in high-risk area of the carotid surgery.