Abstract:
Introduction: alongside with surgical decompression, the treatment of traumatic optical neuropathy implies the administration of substances with neuroprotective effect.
Matherial and Methods: a compressive optic nerve trauma was generated at 40 rats by means of micro lesion equipment. Subsequently, according to an established injection protocol, totally 285 mg/kg/KG/48h of methylprednisolon and 750 mg of flunarizin were administered.
The retina was split up into a central, intermediary, and peripheral visual fields (VF).
Results: the FLU-group shows significantly worse results with respect to both the number and size of ganglion cells in separate VF. However, the difference between the absolute numbers of ganglion cells and surface areas was so minor that from the clinical viewpoint the better effectiveness of either substance was hardly to discern.