Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Kamaraj, Rajamanikkam; Mejdrova, Ivana; Krutakova, Maria; Smutny, Tomas; Skach, Krystof; Dohnalova, Klara; Smutna, Lucie; Nellore, Dharani Sai Sreekanth; Dusek, Jan; Chalupsky, Karel; Hricova, Jana; Kronenberger, Thales; Stahl, Aaron; Templin, Markus; Braeuning, Albert; Nencka, Radim; Pavek, Petr

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Author:

Kamaraj, Rajamanikkam; Mejdrova, Ivana; Krutakova, Maria; Smutny, Tomas; Skach, Krystof; Dohnalova, Klara; Smutna, Lucie; Nellore, Dharani Sai Sreekanth; Dusek, Jan; Chalupsky, Karel; Hricova, Jana; Kronenberger, Thales; Stahl, Aaron; Templin, Markus; Braeuning, Albert; Nencka, Radim; Pavek, Petr

Tübinger Autor(en):

Kronenberger, Thales
Stahl, Aaron
Templin, Markus

Published in:

Journal of Medicinal Chemistry (2025), Bd. 68, H. 14, S. 14271-14299

Verlagsangabe:

Washington : Amer Chemical Soc

Language:

English

Full text:

http://dx.doi.org/10.1021/acs.jmedchem.4c03134

ISSN:

0022-2623