Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Wilhelmsen, Kevin; Deshpande, Aditi; Tronnes, Sarah; Mahanta, Maitriyee; Banicki, Matthew; Cochran, Mary; Cowdin, Samantha; Fortney, Kristen; Hartman, George; Hughes, Robert E.; Montgomery, Rusty; Portillo, Claudia P.; Rubin, Paul; Salazar, Taiz; Wang, Yan; Yan, Shijun; Morgan, Barry A.; Duisembekova, Assem; Riou, Romane; Marleaux, Michael; Hochheiser, Inga V.; Buthmann, Hannes; Ferber, Dominic; Torp, Jane; Wang, Wei; Cranston, Melanie; McKee, Chloe M.; Mawhinney, Thea J.; McKay, Emma C.; Eroglu, Fehime K.; Kummerle-Deschner, Jasmin; Weber, Alexander N. R.; Py, Benedicte F.; Geyer, Matthias; Coll, Rebecca C.

Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action

Autor(en):

Wilhelmsen, Kevin; Deshpande, Aditi; Tronnes, Sarah; Mahanta, Maitriyee; Banicki, Matthew; Cochran, Mary; Cowdin, Samantha; Fortney, Kristen; Hartman, George; Hughes, Robert E.; Montgomery, Rusty; Portillo, Claudia P.; Rubin, Paul; Salazar, Taiz; Wang, Yan; Yan, Shijun; Morgan, Barry A.; Duisembekova, Assem; Riou, Romane; Marleaux, Michael; Hochheiser, Inga V.; Buthmann, Hannes; Ferber, Dominic; Torp, Jane; Wang, Wei; Cranston, Melanie; McKee, Chloe M.; Mawhinney, Thea J.; McKay, Emma C.; Eroglu, Fehime K.; Kummerle-Deschner, Jasmin; Weber, Alexander N. R.; Py, Benedicte F.; Geyer, Matthias; Coll, Rebecca C.

Tübinger Autor(en):

Eroglu, Fehime K.
Weber, Alexander N. R.
Kümmerle-Deschner, Jasmin

Erschienen in:

Journal of Experimental Medicine (2025), Bd. 222 (11), Article e20242403

Verlagsangabe:

New York : Rockefeller Univ Press

Sprache:

Englisch

Referenz zum Volltext:

http://dx.doi.org/10.1084/jem.20242403

ISSN:

0022-1007