Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation

Snaebjornsson, Marteinn T.; Poeller, Philipp; Komkova, Daria; Roehrig, Florian; Schlicker, Lisa; Winkelkotte, Alina M.; Chaves-Filho, Adriano B.; Al-Shami, Kamal M.; Caballero, Carolina Dehesa; Koltsaki, Ioanna; Vogel, Felix C. E.; Frias-Soler, Roberto Carlos; Rudalska, Ramona; Schwarz, Jessica D.; Wolf, Elmar; Dauch, Daniel; Steuer, Ralf; Schulze, Almut

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation

Author:

Snaebjornsson, Marteinn T.; Poeller, Philipp; Komkova, Daria; Roehrig, Florian; Schlicker, Lisa; Winkelkotte, Alina M.; Chaves-Filho, Adriano B.; Al-Shami, Kamal M.; Caballero, Carolina Dehesa; Koltsaki, Ioanna; Vogel, Felix C. E.; Frias-Soler, Roberto Carlos; Rudalska, Ramona; Schwarz, Jessica D.; Wolf, Elmar; Dauch, Daniel; Steuer, Ralf; Schulze, Almut

Tübinger Autor(en):

Rudalska, Ramona
Dauch, Daniel Alexander

Published in:

Nature Metabolism (2025), Bd. 7, H. 2, S. 348–366

Verlagsangabe:

Berlin : Nature Portfolio

Language:

English

Full text:

http://dx.doi.org/10.1038/s42255-024-01201-w

ISSN:

2522-5812