Modelling Sensory Innervation of Cancer Using Organ-on-Chip Technology

Abstract

Research contained in this thesis focuses on the advancement of organ-on-chip technology for the exploration of peripheral sensory innervation in cancer. Simultaneously, it describes an extensive attempt at creating a practical platform that can be leveraged to uncover novel approaches in combating cancer-induced pain and gain insight into the intricate relationship between diseased tissues and pain development at a cellular level. Development of this platform is also expected to produce a versatile system capable of addressing the often-neglected importance of peripheral innervation of various kinds in various organs and tissues. Peripheral nerves are essential in modulating tissue responses to environmental changes and maintaining tissue homeostasis, consequently, when innervation maladapts in conditions such as cancer, it has been associated with the development of pain states and tissue dysfunction. Having a technology that can accurately replicate these processes could prove valuable in facilitating the development of therapeutics aimed at alleviating pain and restoring tissue integrity.