Impact of autonomic nervous system activity and interscapular fat on human glucose metabolism

Abstract

In this cumulative thesis, three studies investigated potential regulators of insulin sensitivity and insulin secretion, the two main pathophysiological contributors in the development of type 2 diabetes. The research project addressed the questions if insulin sensitivity or insulin secretion can be improved by modulating the autonomic nervous system in healthy persons and if interscapular fat is a clinically relevant fat depot with regard to insulin sensitivity, insulin secretion and glucose metabolism.