Design of a Two-in-One Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Wittlinger, Florian; Heppner, David E.; To, Ciric; Guenther, Marcel; Shin, Bo Hee; Rana, Jaimin K.; Schmoker, Anna M.; Beyett, Tyler S.; Berger, Lena M.; Berger, Benedict-Tilman; Bauer, Nicolas; Vasta, James D.; Corona, Cesear R.; Robers, Matthew B.; Knapp, Stefan; Janne, Pasi A.; Eck, Michael J.; Laufer, Stefan A.

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Design of a Two-in-One Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Author:

Wittlinger, Florian; Heppner, David E.; To, Ciric; Guenther, Marcel; Shin, Bo Hee; Rana, Jaimin K.; Schmoker, Anna M.; Beyett, Tyler S.; Berger, Lena M.; Berger, Benedict-Tilman; Bauer, Nicolas; Vasta, James D.; Corona, Cesear R.; Robers, Matthew B.; Knapp, Stefan; Janne, Pasi A.; Eck, Michael J.; Laufer, Stefan A.

Tübinger Autor(en):

Wittlinger, Florian
Laufer, Stefan
Günther, Marcel Benjamin

Published in:

Journal of Medicinal Chemistry (2022), Bd. 65, H. 2, S. 1370-1383

Verlagsangabe:

Amer Chemical Soc

Language:

English

Full text:

http://dx.doi.org/10.1021/acs.jmedchem.1c00848

ISSN:

0022-2623