Optimizing deep brain stimulation using electrophysiological markers and electrical field steering

DSpace Repository

Show simple item record

dc.contributor.advisor Gharabaghi, Alireza (Prof. Dr.)
dc.contributor.author Scherer, Maximilian
dc.date.accessioned 2022-01-13T16:29:54Z
dc.date.available 2022-01-13T16:29:54Z
dc.date.issued 2023-11-23
dc.identifier.uri http://hdl.handle.net/10900/122907
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1229072 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-64271
dc.description.abstract Deep brain stimulation (DBS) is an effective treatment for a wide variety of neurological disorders. The efficacy of the treatment strongly depends on the exact location of the DBS-lead within the brain and the programming of the stimulation. In this work, methods and markers are presented which may be applied to improve both, the positioning and the programming of DBS-leads. Special consideration was given to ensure that any identified potential marker was not only a general effect of the stimulation itself, but actually a marker of clinical benefit. One method for achieving this goal was to investigate whether a qualitative change in clinical improvement was reflected in a qualitative change regarding an electrophysiological marker candidate. A second method to identify markers specific for clinical improvement was to separate the available data into patients responding to the treatment and patients not responding to the treatment. Therefore, potential marker candidates had to be present in the responder data, but absent in the non-responder data. Generally, marker candidates were discarded when they were strongly confounded by other effects like movement. DBS programming was not only optimized by providing more reliably sources of information during the programming process, but also by evaluating the effect of steering the electrical field. To this end, the clinical utility of segment DBS-lead contacts was compared to ring DBS-lead contacts. Refining of the implantation procedure itself was explored when a novel method to implant the DBS-leads into patients with Parkinson’s disease was investigated. This method allowed for the inclusion of electrophysiological information to the implantation process without the need to a priori record electrophysiological information with either a micro- or macro-electrode. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.ddc 000 de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 610 de_DE
dc.title Optimizing deep brain stimulation using electrophysiological markers and electrical field steering en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2021-09-22
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.noppn yes de_DE

Dateien:

This item appears in the following Collection(s)

Show simple item record