Browsing Universitätsbibliographie by Author "Zimmermann, Markus O."

Now showing items 1-20 of 20

Development of tools and methods for the analysis, visualization, and prediction of halogen bonding in molecular design and drug design

Zimmermann, Markus O. (2015)
Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity

Fischer, Stefan; Wentsch, Heike K.; Mayer-Wrangowski, Svenja C.; Zimmermann, Markus; Bauer, Silke M.; Storch, Kirsten; Niess, Raimund; Koeberle, Solveigh C.; Gruetter, Christian; Boeckler, Frank M.; Rauh, Daniel; Laufer, Stefan A. (2013)
Discovery of Ircinianin Lactones B and C-Two New Cyclic Sesterterpenes from the Marine Sponge Ircinia wistarii

Majer, Thomas; Bhattarai, Keshab; Straetener, Jan; Pohlmann, Justus; Cahill, Patrick; Zimmermann, Markus O.; Huebner, Marc P.; Kaiser, Marcel; Svenson, Johan; Schindler, Michael; Broetz-Oesterhelt, Heike; Boeckler, Frank M.; Gross, Harald (2022)
Evaluating the Potential of Halogen Bonding in Molecular Design: Automated Scaffold Decoration Using the New Scoring Function XBScore

Zimmermann, Markus O.; Lange, Andreas; Boeckler, Frank M. (2015)
Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

Wilcken, Rainer; Zimmermann, Markus O.; Bauer, Matthias R.; Rutherford, Trevor J.; Fersht, Alan R.; Joerger, Andreas C.; Boeckler, Frank M. (2015)
Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

Zimmermann, Markus O.; Lange, Andreas; Wilcken, Rainer; Cieslik, Markus B.; Exner, Thomas E.; Joerger, Andreas C.; Koch, Pierre; Boeckler, Frank M. (2014)
Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Wilcken, Rainer; Liu, Xiangrui; Zimmermann, Markus O.; Rutherford, Trevor J.; Fersht, Alan R.; Joerger, Andreas C.; Boeckler, Frank M. (2012)
Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter

Banjac, Ana; Zimmermann, Markus O.; Boeckler, Frank M.; Kurz, Ursula; Schultz, Anita; Schultz, Joachim E. (2012)
Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Wilcken, Rainer; Zimmermann, Markus O.; Lange, Andreas; Joerger, Andreas C.; Boeckler, Frank M. (2013)
Quadruple Target Evaluation of Diversity-Optimized Halogen-Enriched Fragments (HEFLibs) Reveals Substantial Ligand Efficiency for AP2-Associated Protein Kinase 1 (AAK1)

Dammann, Marcel; Kramer, Markus; Zimmermann, Markus O.; Boeckler, Frank M. (2022)
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C

Stahlecker, Jason; Klett, Theresa; Schwer, Martin; Jaag, Simon; Dammann, Marcel; Ernst, Larissa N.; Braun, Michael B.; Zimmermann, Markus O.; Kramer, Markus; Lammerhofer, Michael; Stehle, Thilo; Coles, Murray; Boeckler, Frank M. (2022)
Scaffold Effects on Halogen Bonding Strength

Lange, Andreas; Heidrich, Johannes; Zimmermann, Markus O.; Exner, Thomas E.; Boeckler, Frank M. (2019)
Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes

Dammann, Marcel; Stahlecker, Jason; Zimmermann, Markus O.; Klett, Theresa; Rotzinger, Kilian; Kramer, Markus; Coles, Murray; Stehle, Thilo; Boeckler, Frank M. (2022)
Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4

Vaas, Sebastian; Zimmermann, Markus O.; Klett, Theresa; Boeckler, Frank M. (2023)
Targeting Histidine Side Chains in Molecular Design through Nitrogen-Halogen Bonds

Lange, Andreas; Zirnmermann, Markus O.; Wilcken, Rainer; Zahn, Stefan; Boeckler, Frank M. (2013)
Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Lange, Andreas; Guenther, Marcel; Buettner, Felix Michael; Zimmermann, Markus O.; Heidrich, Johannes; Hennig, Susanne; Zahn, Stefan; Schall, Christoph; Sievers-Engler, Adrian; Ansideri, Francesco; Koch, Pierre; Laemmerhofer, Michael; Stehle, Thilo; Laufer, Stefan A.; Boeckler, Frank M. (2015)
Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and pi...pi interactions using N-methylacetamide

Zimmermann, M. O.; Boeckler, F. M. (2016)
Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Abu Thaher, Bassam; Arnsmann, Martina; Totzke, Frank; Ehlert, Jan E.; Kubbutat, Michael H. G.; Schaechtele, Christoph; Zimmermann, Markus O.; Koch, Pierre; Boeckler, Frank M.; Laufer, Stefan A. (2012)
Using halogen bonds to address the protein backbone: a systematic evaluation

Wilcken, Rainer; Zimmermann, Markus O.; Lange, Andreas; Zahn, Stefan; Boeckler, Frank M. (2012)
Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine

Zimmermann, Markus O.; Lange, Andreas; Zahn, Stefan; Exner, Thomas E.; Boeckler, Frank M. (2016)

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